TRK-851-药物合成数据库

【药物名称】TRK-851

化学结构式(Chemical Structure):

参考文献No.	32967
标题:	Indole derivs. and medicinal use thereof
作者:	Nagase, H.; Kawai, K.; Endo, T.; Ueno, S.; Maeda, M.; Sakami, S. (Toray Industries, Inc.)
来源:	EP 0805157; US 5849731; WO 9711948

合成路线图解说明: The title polycyclic compound was synthesized by Fisher indolization of naltrexone (I) with 1-amino-6-fluoro-1,2,3,4-tetrahydroquinoline (II) in the presence of methanesulfonic acid in refluxing EtOH.

参考文献No.	601169
标题:	Rational drug design and synthesis of opioid delta-receptor selective antagonist TRK-851 and its antitussive activity
作者:	Maeda, M.; et al.
来源:	20th Symp Med Chem (Dec 6 2000, Tokyo) 2000,Abst 1P-16

合成路线图解说明: The title polycyclic compound was synthesized by Fisher indolization of naltrexone (I) with 1-amino-6-fluoro-1,2,3,4-tetrahydroquinoline (II) in the presence of methanesulfonic acid in refluxing EtOH.