【药物名称】APCP-363, APO-363
化学结构式(Chemical Structure):
参考文献No.45726
标题:Novel orally active iron (III) chelators
作者:Tilbrook, G.S.; Hider, R.C.; Liu, Z. (BTG International Ltd.)
来源:WO 9854138
合成路线图解说明:

Treatment of allomaltol (I) with acetaldehyde (II) and NaOH in H2O affords pyranone derivative (III), which is benzylated by means of benzyl bromide (IV) and NaOH in refluxing H2O/MeOH to provide compound (V). O-Methylation of (V) by reaction with NaH and MeI in DMF furnishes methoxyethyl derivative (VI), which is then heated with methylamine and NaOH in EtOH/H2O to yield pyridinone derivative (VII). Finally, the benzyl group of (VII) is removed by hydrogenation over Pd/C in MeOH to give the desired product.

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