S-151276, S-15176-药物合成数据库

【药物名称】S-151276, S-15176

化学结构式(Chemical Structure):

参考文献No.	20311
标题:	Trimetazidine derivs., process for their preparation and pharmaceutical compsns. containing them
作者:	Regnier, G.; Vilaine, J.-P.; Villeneuve, N.; Bidouard, J.-P.; Iliou, J.-P.; Lenaers, A. (ADIR et Cie.)
来源:	EP 0533579; FR 2681324; JP 1993194451; US 5283246

合成路线图解说明: The condensation between bromide (I) and piperazine (II) in refluxing acetonitrile provided the disubstituted piperazine (III). The acetate ester was then hydrolyzed by means of NaOH to yield the title compound.