Ro-0094889, Ro-09-4889-药物合成数据库

【药物名称】Ro-0094889, Ro-09-4889

化学结构式(Chemical Structure):

参考文献No.	37833
标题:	5'-Deoxy-cytidine derivs.
作者:	Hattori, K.; Suda, H.; Ishikawa, T.; Shimma, N.; Kohchi, Y.; Oikawa, N.; Ishitsuka, H. (F. Hoffmann-La Roche AG)
来源:	DE 19823484; EP 0882734; ES 2142763; FR 2763953; GB 2325931; JP 1998330395

合成路线图解说明: Silylation of 5-iodocytosine (I) with hexamethyldisilazane, followed by condensation with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranoside (II) in the presence of stannic chloride provided 2',3'-di-O-acetyl-5'-deoxy-5-iodocytidine (III). The title vinylcytidine derivative was then obtained by displacement of the iodine atom of (III) with tri-n-butyl(vinyl)stannane (IV) using palladium catalyst and trifurylphosphine.

参考文献No.	40149
标题:	5'-Deoxycytidine derivs.
作者:	Ishitsuka, H.; Kohchi, Y.; Shimma, N.; Oikawa, N.; Hattori, K.; Suda, H.; Ishikawa, T. (F. Hoffmann-La Roche AG)
来源:	EP 1060183; WO 9940099

合成路线图解说明: Silylation of 5-iodocytosine (I) with hexamethyldisilazane, followed by condensation with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranoside (II) in the presence of stannic chloride provided 2',3'-di-O-acetyl-5'-deoxy-5-iodocytidine (III). The title vinylcytidine derivative was then obtained by displacement of the iodine atom of (III) with tri-n-butyl(vinyl)stannane (IV) using palladium catalyst and trifurylphosphine.