-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	39777
标题:	Inhibition of p38 kinase activity using substd. heterocyclic ureas
作者:	Riedl, B.; Lee, W.; Lowinger, T.B.; Redman, A.; Smith, R.A.; Khire, U.; Dumas, J.; Scott, W.J.; Wood, J.E.; Johnson, J.; Paulsen, H.; Hatoum-Mokdad, H. (Bayer Corp.)
来源:	WO 9932111

合成路线图解说明: In a related procedure, amino isoxazole (IV) was converted to the corresponding isocyanate (VI) by treatment with phosgene and pyridine. Isocyanate (VI) was then condensed with amine (III), producing the target urea.

合成路线图解说明: 4-(4-Pyridinylmethyl)aniline (II) was prepared by catalytic hydrogenation of the corresponding nitro derivative (I) over Pd/C. Condensation of aniline (II) with N,N?carbonyldiimidazole produced the imidazolide (III). This was then condensed with 5-amino-3-tert-butyl-1-methylpyrazole (IV) to furnish the target urea.

参考文献No.	39781
标题:	Inhibition of raf kinase using substd. heterocyclic ureas
作者:	Redman, A.; Paulsen, H.; Lowinger, T.B.; Dumas, J.; Johnson, J.; Wood, J.E.; Scott, W.J.; Khire, U.; Hatoum-Mokdad, H.; Lee, W.; Smith, R.A.; Riedl, B. (Bayer Corp.)
来源:	EP 1047418; WO 9932106

合成路线图解说明: Condensation of 4-aminophenol (I) with 4-chloropyridine (II) in the presence of potassium tert-butoxide afforded the intermediate diaryl ether (III).

合成路线图解说明: Treatment of 3-amino-5-tert-butylisoxazole (IV) with carbonyldiimidazole produced the imidazolide (V), which was then condensed with amine (III) to furnish the title urea.

合成路线图解说明: 4-(4-Pyridinylmethyl)aniline (II) was prepared by catalytic hydrogenation of the corresponding nitro derivative (I) over Pd/C. Condensation of aniline (II) with N,N?carbonyldiimidazole produced the imidazolide (III). This was then condensed with 5-amino-3-tert-butyl-1-methylpyrazole (IV) to furnish the target urea.