The reductive alkylation of cyclooctylamine (II) with N-Boc-4-piperidinone (I) in the presence of sodium cyanoborohydride afforded the secondary amine (III), which was condensed with propionyl chloride, yielding amide (IV). Deprotection of the Boc group of (IV) by means of HCl in dioxan provided piperidine (V). This was finally alkylated with 1-(3-chloropropoxy)-4-fluorobenzene (VI) to furnish the title compound.