ICA-17043-药物合成数据库

【药物名称】ICA-17043

化学结构式(Chemical Structure):

参考文献No.	50857
标题:	Gardos channel antagonists
作者:	Rigdon, G.C.; McNaughton-Smith, G.A.; Stocker, J.W. (ICAgen, Inc.)
来源:	EP 1158971; US 6288122; WO 0050026

合成路线图解说明: The Grignard condensation of 4,4'-difluorobenzophenone (I) with phenylmagnesium bromide (II) in refluxing tert-butyl methyl ether gives the corresponding carbinol (III), which is treated with acetyl chloride in dichloromethane to yield the methyl chloride (IV). Condensation of compound (IV) with copper cyanide by heating at 140 癈, followed by treatment with hot toluene affords 2,2-bis(4-fluorophenyl)-2-phenylacetonitrile (V), which is finally partially hydrolyzed with H2SO4 in refluxing glacial acetic acid.

参考文献No.	756248
标题:	ICA-17043
作者:	Chilman-Blair, K.; Casta馿r, J.; Leeson, P.A.
来源:	Drugs Fut 2003,28(9),854

合成路线图解说明: The Grignard condensation of 4,4'-difluorobenzophenone (I) with phenylmagnesium bromide (II) in refluxing tert-butyl methyl ether gives the corresponding carbinol (III), which is treated with acetyl chloride in dichloromethane to yield the methyl chloride (IV). Condensation of compound (IV) with copper cyanide by heating at 140 癈, followed by treatment with hot toluene affords 2,2-bis(4-fluorophenyl)-2-phenylacetonitrile (V), which is finally partially hydrolyzed with H2SO4 in refluxing glacial acetic acid.