CDRI-93/478-药物合成数据库

【药物名称】CDRI-93/478

化学结构式(Chemical Structure):

参考文献No.	45847
标题:	1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and their use in medical treatments
作者:	Jain, S.; Sinha, N.; Saxena, A.K.; Anand, N.; Saxena, R.M.; Dubey, M.P.; Patnaik, G.K.; Ray, M. (Council of Scientific and Industrial Research)
来源:	US 6150367

合成路线图解说明: The title compound was synthesized by two related methods. 2-Pyrrolidone (I) was alkylated with 1-bromo-3-chloropropane (II) using either sodium or potassium metal or potassium tert-butoxide as the base. The resultant N-(3-chloropropyl)pyrrolidone (III) was then condensed with 1-(4-fluorophenyl)piperazine (IV) in the presence of NaI and Na2CO3 to produce the desired disubstituted piperazine. Alternatively, the title compound was prepared from the known N-(3-chloropropyl)-N'-(4-fluorophenyl)piperazine (V) by condensation with 2-pyrrolidone (I) in the presence of sodium metal in hot xylene.

参考文献No.	52794
标题:	Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes
作者:	Jain, S.; Sinha, N.; Saxena, A.K.; Anand, N.; Saxena, R.M.; Dubey, M.P.; Patnaik, G.K.; Ray, M. (Council of Scientific and Industrial Research)
来源:	US 6084097

合成路线图解说明: The title compound was synthesized by two related methods. 2-Pyrrolidone (I) was alkylated with 1-bromo-3-chloropropane (II) using either sodium or potassium metal or potassium tert-butoxide as the base. The resultant N-(3-chloropropyl)pyrrolidone (III) was then condensed with 1-(4-fluorophenyl)piperazine (IV) in the presence of NaI and Na2CO3 to produce the desired disubstituted piperazine. Alternatively, the title compound was prepared from the known N-(3-chloropropyl)-N'-(4-fluorophenyl)piperazine (V) by condensation with 2-pyrrolidone (I) in the presence of sodium metal in hot xylene.