SL-11093-药物合成数据库

【药物名称】SL-11093

化学结构式(Chemical Structure):

参考文献No.	47059
标题:	Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
作者:	Marton, L.J.; Frydman, B. (SLIL Biomedical Corp.)
来源:	WO 0066175

合成路线图解说明: Alkylation of N-ethyl mesitylenesulfonamide (I) with 4-bromobutyronitrile (II) in the presence of NaH afforded the cyano sulfonamide (III). After catalytic hydrogenation of the cyano group of (III), the resulting amine (IV) was acylated with mesitylenesulfonyl chloride (V) to give the bis-sulfonamide (VI) (1). Subsequent condensation of (VI) with the bis-sulfonate (VII) produced the tetra-sulfonamide (VIII). Finally, cleavage of the mesitylenesulfonyl protecting groups of (VIII) using HBr in HOAc furnished the corresponding tetraamine, which was isolated as the hydrochloride salt.

参考文献No.	603970
标题:	Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cells
作者:	Valasinas, A.; Sarkar, A.; Reddy, V.K.; Marton, L.J.; Basu, H.S.; Frydman, B.
来源:	J Med Chem 2001,44(3),390

合成路线图解说明: Alkylation of N-ethyl mesitylenesulfonamide (I) with 4-bromobutyronitrile (II) in the presence of NaH afforded the cyano sulfonamide (III). After catalytic hydrogenation of the cyano group of (III), the resulting amine (IV) was acylated with mesitylenesulfonyl chloride (V) to give the bis-sulfonamide (VI) (1). Subsequent condensation of (VI) with the bis-sulfonate (VII) produced the tetra-sulfonamide (VIII). Finally, cleavage of the mesitylenesulfonyl protecting groups of (VIII) using HBr in HOAc furnished the corresponding tetraamine, which was isolated as the hydrochloride salt.