【药物名称】MnTDE-2-ImP5+, AEOL-10150
化学结构式(Chemical Structure):
参考文献No.46467
标题:Substd. porphyrins
作者:Trova, M.P.; Kitchen, D.B.; Crapo, J.D.; Gauuan, P.J.F.; Day, B.J. (National Jewish Medical and Research Center)
来源:EP 1155019; JP 2002535332; WO 0043395
合成路线图解说明:

The tetraimidazolyl porphyrin (III) was prepared by reaction between 1-ethylimidazole-2-carboxaldehyde (I) and pyrrole (II) in refluxing propionic acid. Quaternization of the imidazole groups of (III) with iodoethane furnished the tetrakis-imidazolium iodide salt (IV). After complexation of porphyrin (IV) with manganese(III) acetate, its precipitation as the hexafluorophosphate salt followed by anion exchange with tetrabutylammonium chloride, furnished the title chelate pentachloride salt.

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