【药物名称】
化学结构式(Chemical Structure):
参考文献No.603466
标题:exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: Syntheses and nicotinic acetylcholine agonist activity of potent pyridazine analogues of (?-epibatidine
作者:Che, D.; Wegge, T.; Stubbs, M.T.; Seitz, G.; Meier, H.; Methfessel, C.
来源:J Med Chem 2001,44(1),47
合成路线图解说明:

The bicyclic ester (I) was reduced to alcohol (II) using LiBH4. Subsequent Swern oxidation of (II) afforded aldehyde (III). Wittig reaction of aldehyde (III) with methoxymethylene triphenylphosphorane gave rise to the enol ether (IV). Diels-Alder reaction of (IV) with tetrazine (V), with concomitant elimination of nitrogen, furnished the pyridiazine (VI). Finally, acid hydrolysis of the carbamate group of (VI) provided the title compound.

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