【药物名称】
化学结构式(Chemical Structure):
参考文献No.46901
标题:Peroxide-based antimalarial cpds.
作者:Ward, S.A.; O'Neill, P.M. (Ultrafine Ltd.)
来源:WO 0104123
合成路线图解说明:

Coupling of dihydroartemisinin (I) with p-trifluoromethylphenol (II) in the presence of trimethylsilyl triflate and silver perchlorate at -78 C produced the corresponding aryl ether as an epimeric mixture. The major 10-beta isomer was then isolated from the reaction mixture by column chromatography.

参考文献No.603467
标题:Synthesis, antimalarial activity, biomimetic iron(I) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin
作者:O'Neill, P.M.; Miller, A.; Bishop, L.P.D.; Hindley, S.; Maggs, J.L.; Ward, S.A.; Roberts, S.M.; Scheinmann, F.; Stachulski, A.V.; Posner, G.H.; Park, B.K.
来源:J Med Chem 2001,44(1),58
合成路线图解说明:

Coupling of dihydroartemisinin (I) with p-trifluoromethylphenol (II) in the presence of trimethylsilyl triflate and silver perchlorate at -78 C produced the corresponding aryl ether as an epimeric mixture. The major 10-beta isomer was then isolated from the reaction mixture by column chromatography.

参考文献No.615103
标题:Application of the TMSOTf-AgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin
作者:O'Neill, P.M.; et al.
来源:Tetrahedron Lett 1999,40(51),9129
合成路线图解说明:

Coupling of dihydroartemisinin (I) with p-trifluoromethylphenol (II) in the presence of trimethylsilyl triflate and silver perchlorate at -78 C produced the corresponding aryl ether as an epimeric mixture. The major 10-beta isomer was then isolated from the reaction mixture by column chromatography.

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