-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	608311
标题:	Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195)
作者:	Cappelli, A.; Anzini, M.; Vomero, S.; De Benedetti, P.G.; Menziani, M.C.; Giorgi, G.; Manzoni, C.
来源:	J Med Chem 1997,40(18),2910

合成路线图解说明: Friedl鋘der cyclization between 2-aminobenzophenone (I) and 2-oxobutyric acid (II) by means of NaOMe in MeOH gives carboxylic acid (III), which is then converted into the corresponding acid chloride (IV) by reaction with SOCl2 in CH2Cl2. Finally, the target product is obtained by reaction of (IV) with N-methylbenzylamine (V) by means of Et3N.

参考文献No.	635388
标题:	Synthesis of 2-substituted 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-3-ones as potential peripheral benzodiazepine-receptor ligands
作者:	Anzini, M.; et al.
来源:	Heterocycles 1994,38(1),103

合成路线图解说明: Friedl鋘der cyclization between 2-aminobenzophenone (I) and 2-oxobutyric acid (II) by means of NaOMe in MeOH gives carboxylic acid (III), which is then converted into the corresponding acid chloride (IV) by reaction with SOCl2 in CH2Cl2. Finally, the target product is obtained by reaction of (IV) with N-methylbenzylamine (V) by means of Et3N.