QAB-205, NVP-QAB-205, NVP-QAB-205-AA-药物合成数据库

【药物名称】QAB-205, NVP-QAB-205, NVP-QAB-205-AA

化学结构式(Chemical Structure):

参考文献No.	47638
标题:	Purine derivs. inhibitors of tyrosine protein kinase syk
作者:	Menear, K.A.; Mattes, H.; Collingwood, S.P.; Walker, C.V.; Hayler, J.; Le Grand, D.M.; Cockcroft, X.-L. (Novartis AG; Novartis-Erfindungen VmbH)
来源:	EP 1200435; WO 0109134

合成路线图解说明: 2,6-Dichloropurine (I) is condensed with cyclobutylamine (II) in the presence of diisopropylethylamine in hot butanol to produce the 6-cyclobutylamino purine (III). The 2-chloro group of purine (III) is then displaced with 4-amino-N-methylacetanilide (IV) in N-methylpyrrolidone at 145 C to furnish the target diamino purine derivative.

参考文献No.	686796
标题:	Novel 2,6-disubstituted purines - The synthesis of potent and selective inhibitors of the protein tyrosine kinase Syk
作者:	Bammerlin, H.; Le Grand, D.; Hayler, J.; et al.
来源:	Drugs Fut 2002,27(Suppl. A),

合成路线图解说明: 2,6-Dichloropurine (I) is condensed with cyclobutylamine (II) in the presence of diisopropylethylamine in hot butanol to produce the 6-cyclobutylamino purine (III). The 2-chloro group of purine (III) is then displaced with 4-amino-N-methylacetanilide (IV) in N-methylpyrrolidone at 145 C to furnish the target diamino purine derivative.