(-)-2-(2-Bromohexadecanoyl)paclitaxel, BrC16HT, (-)-BRT-216-药物合成数据库

【药物名称】(-)-2-(2-Bromohexadecanoyl)paclitaxel, BrC16HT, (-)-BRT-216

化学结构式(Chemical Structure):

参考文献No.	48315
标题:	Hydrolysis-promoting hydrophobic taxane derivs.
作者:	Mayhew, E.; Janoff, A.S.; Bhattacharya, S.; Kehane, G.; Ahmad, I.; Franklin, J.C.; Ali, S. (The Liposome Company, Ltd.)
来源:	US 6107332

合成路线图解说明: Esterification of Taxol (paclitaxel) (I) with 2-bromohexadecanoic acid (II) by means of DCC in dichloromethane yields the target 2'-(2-bromohexadecanoyl)paclitaxel.

参考文献No.	625471
标题:	Hydrolyzable hydrophobic taxanes: Synthesis and anti-cancer activities
作者:	Ali, S.; Ahmad, I.; Peters, A.; Masters, G.; Minchey, S.; Janoff, A.; Mayhew, E.
来源:	Anti-Cancer Drugs 2001,12(2),117

合成路线图解说明: The target compound is obtained by esterification of Taxol (paclitaxel) (I) with hexadecanoic anhydride (II) by means of DCC in dichloromethane.

合成路线图解说明: Esterification of Taxol (paclitaxel) (I) with 2-bromohexadecanoic acid (II) by means of DCC in dichloromethane yields the target 2'-(2-bromohexadecanoyl)paclitaxel.