【药物名称】SP-600125
化学结构式(Chemical Structure):
参考文献No.47900
标题:Pyrazoloanthrone and derivs. thereof as JNK inhibitors and their compsns.
作者:O'Leary, E.C.; Satoh, Y.; Manning, A.M.; Bhagwat, S.S.; Bennett, B.L.; Murray, B.W. (Signal Pharmaceuticals, Inc.)
来源:WO 0112609
合成路线图解说明:

The title anthrapyrazolone was synthesized by condensation of 2-chloroanthraquinone (I) with anhydrous hydrazine in pyridine at 100 C. Purification of the compound was achieved via conversion to the N-acetyl derivative, which recrystallized from HOAc, followed by hydrolysis of the acetyl group with ammonium hydroxide in MeOH.

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