RHPS04, NSC-714187, RHPS4-药物合成数据库

【药物名称】RHPS04, NSC-714187, RHPS4

化学结构式(Chemical Structure):

参考文献No.	650865
标题:	Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts
作者:	Heald, R.A.; Modi, C.; Cookson, J.C.; Hutchinson, I.; Laughton, C.A.; Gowan, S.M.; Kelland, L.R.; Stevens, M.F.G.
来源:	J Med Chem 2002,45(3),590

合成路线图解说明: The title compound was obtained in a one-pot procedure by dimerization of 1,2-dimethyl-6-fluoroquinolinium methosulfate (I) in ethanolic piperidine, giving intermediate (II), which spontaneously rearranged to the title quinoacridinium salt.

合成路线图解说明: The title compound was obtained in a one-pot procedure by dimerization of 1,2,6-trimethylquinolinium methosulfate (I) in ethanolic piperidine, giving intermediate (II), which spontaneously rearranged to the title quinoacridinium salt.