T-1317, T-0901317-药物合成数据库

【药物名称】T-1317, T-0901317

化学结构式(Chemical Structure):

参考文献No.	46923
标题:	Compsns. and methods for raising HDL cholesterol levels
作者:	Shan, B. (Tularik Inc.)
来源:	WO 0103705

合成路线图解说明: Treatment of aniline (I) with hexafluoroacetone trihydrate (II) and p-toluenesulfonic acid affords derivative (III), which is then derivatized with trifluoroacetic anhydride (IV) to provide trifluoroacetanilide derivative (V). Reduction of (V) by means of LiAlH4 in refluxing THF yields N-trifluoroethylaniline derivative (VI), which is finally converted into the target sulfonamide by reaction with benzenesulfonyl chloride (VII) in pyridine.

合成路线图解说明: The target compound is obtained by sulfonylation of aniline (I) with benzenesulfonyl chloride (II) in MeOH.

参考文献No.	51576
标题:	LXR modulators
作者:	Liu, J.; Li, L.; Cutler, S.T.; Zhu, L.; Shan, B.; Medina, J.C.; Hasegawa, H.; Lustig, K. (Tularik Inc.)
来源:	EP 1161233; WO 0054759

合成路线图解说明: Treatment of aniline (I) with hexafluoroacetone trihydrate (II) and p-toluenesulfonic acid affords derivative (III), which is then derivatized with trifluoroacetic anhydride (IV) to provide trifluoroacetanilide derivative (V). Reduction of (V) by means of LiAlH4 in refluxing THF yields N-trifluoroethylaniline derivative (VI), which is finally converted into the target sulfonamide by reaction with benzenesulfonyl chloride (VII) in pyridine.