【药物名称】ST-368
化学结构式(Chemical Structure):
参考文献No.613186
标题:Nonbenzamidine isoxazolin derivatives as factor Xa inhibitors
作者:Wong, P.C.; Ellis, C.D.; Rossi, K.A.; Wexler, R.R.; Wright, M.R.; Quan, M.L.; Lam, P.Y.; He, M.Y.; Knabb, R.M.; Liauw, A.Y.
来源:221st ACS Natl Meet (April 1 2001, San Diego) 2001,Abst MEDI 52
合成路线图解说明:

Conversion of the bromo derivative (I) into the corresponding azido compound (II) is performed by treatment with NaN3 in DMSO. Separately, aldehyde (III) is treated with hydroxylamine to provide oxime (IV), which is then condensed with derivative (II) by means of bleach in CH2Cl2 to furnish isoxazoline derivative (V). Hydrolysis of the methyl ester of (V) by means of LiOH in THF affords carboxylic acid (VI), which is treated with SOCl2 and then condensed with amine (VII) by means of Et3N to give carboxamide (VIII). Reduction of the azido moiety of (VIII) by means of P(OEt)3 in THF yields amine (IX), which is then derivatized by reaction with mesyl chloride (MeSO2Cl) to provide mesylate (X). Finally, the desired compound is obtained by treatment of (X) with TFA for tert-butyl group removal, followed by reduction of the nitro moiety with SnCl2.

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