CRL-8299-药物合成数据库

【药物名称】CRL-8299

化学结构式(Chemical Structure):

参考文献No.	45009
标题:	Pharmaceutical compsn. based on polyaromatic cpds.
作者:	Kiss, R.; Bontemps-Subielos, N.; Frydman, A.; Darro, F.; Bastide, J.; Deflourne, E. (Laboratoires L. Lafon)
来源:	FR 2790954; WO 0055160

合成路线图解说明: The cyclization of quinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III), which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.

合成路线图解说明: The cyclization of dimethylhydrazone (I) with 4-methoxyquinoline-5,8-dione (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III), which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.

合成路线图解说明: The cyclization of 4-methoxyquinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.

合成路线图解说明: The cyclization of dimethylhydrazone (I) with quinoline-5,8-dione (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.

参考文献No.	633494
标题:	Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid
作者:	Delfourne, E.; Darro, F.; Bontemps-Subielos, N.; Decaestecker, C.; Bastide, J.; Frydman, A.; Kiss, R.
来源:	J Med Chem 2001,44(20),3275

合成路线图解说明: The cyclization of quinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III), which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.

合成路线图解说明: The cyclization of dimethylhydrazone (I) with 4-methoxyquinoline-5,8-dione (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III), which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.

合成路线图解说明: The cyclization of 4-methoxyquinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.

合成路线图解说明: The cyclization of dimethylhydrazone (I) with quinoline-5,8-dione (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.