【药物名称】HMR-1372
化学结构式(Chemical Structure):
参考文献No.42701
标题:Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers
作者:G鰃elein, H.; Bohn, H.; Heitsch, H.; Englert, H.C.; Gerlach, U.; Wirth, K. (Aventis Pharma Deutschland GmbH)
来源:DE 19841534; EP 1117409; WO 0015204
合成路线图解说明:

Coupling between ethylamine derivative (I) and acid chloride (II) by means of DMAP in pyridine affords benzamide (III), which is then subjected to reaction with chlorosulfonic acid followed by treatment with aqueous ammonia to provide benzenesulfonamide (IV). Finally, the desired product is obtained by condensation of (IV) with methyl isothiocyanate in DMF by means of K2CO3.

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