A-278637-药物合成数据库

【药物名称】A-278637

化学结构式(Chemical Structure):

参考文献No.	39699
标题:	Potassium channel openers
作者:	Drizin, I.; Holladay, M.W.; Carroll, W.A.; Zhang, H.Q.; Sullivan, J.P. (Abbott Laboratories Inc.)
来源:	EP 1040097; US 6265417; WO 9931059

合成路线图解说明: The Hantzsch reaction between 3-oxotetrahydrothiophene-1,1-dioxide (I), 3-bromo-4-fluorobenzaldehyde (II) and 3-amino-2-cyclohexen-1-one (III) in refluxing EtOH yielded the hydroxy tetrahydropyridine derivative (IV). Dehydration of the cyclic hemiaminal function of (IV) was carried out in refluxing toluene to produce the racemic dihydropyridine, which was resolved into the individual enantiomers by chiral HPLC.

参考文献No.	630302
标题:	Novel sulfonyldihydropyridine potassium channel openers with potential utility in the treatment of overactive bladder (OAB)
作者:	Drizin, I.; et al.
来源:	222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001,Abst MEDI 197

合成路线图解说明: The Hantzsch reaction between 3-oxotetrahydrothiophene-1,1-dioxide (I), 3-bromo-4-fluorobenzaldehyde (II) and 3-amino-2-cyclohexen-1-one (III) in refluxing EtOH yielded the hydroxy tetrahydropyridine derivative (IV). Dehydration of the cyclic hemiaminal function of (IV) was carried out in refluxing toluene to produce the racemic dihydropyridine, which was resolved into the individual enantiomers by chiral HPLC.