Letosteine-药物合成数据库

【药物名称】Letosteine

化学结构式(Chemical Structure):

参考文献No.	900273
标题:
作者:	Chodkiewicz, M.X.
来源:	BE 812653; DE 2410307; FR 2222087; GB 1452207; JP 74126666; JP 7741262; NL 7403785; US 4032534

合成路线图解说明: The condensation of acrolein (I) with ethyl mercaptoacetate (II) by means of triethylamine in ether gives ethyl 3-oxopropylmercaptoacetate (III), which is then cyclized with cystein (IV) in ethanol - water.

参考文献No.	950012
标题:	Letosteine
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Neuman, M.
来源:	Drugs Fut 1979,4(10),729

合成路线图解说明: The condensation of acrolein (I) with ethyl mercaptoacetate (II) by means of triethylamine in ether gives ethyl 3-oxopropylmercaptoacetate (III), which is then cyclized with cystein (IV) in ethanol - water.