【药物名称】Endralazine, Migranal
化学结构式(Chemical Structure):
参考文献No.900277
标题:
作者:Schenker, E.
来源:DE 2221808; FR 2137692
合成路线图解说明:

1-Ethoxycarbonyl-4-piperidone (I) is treated with pyrrolidine (II) and then with ethyl bromoacetate (IV) to give ethyl 1-ethoxycarbonyl-4-piperidone-3-acetate (VI) which is cyclized with hydrazine to (VII). Bromination, reaction with phosphorous oxychloride, and then with benzoylchloride (XI) leads to (XII) which affords the title compound with hydrazine.

参考文献No.900278
标题:
作者:Schenker, E.
来源:CH 565797
合成路线图解说明:

1-Ethoxycarbonyl-4-piperidone (I) is treated with pyrrolidine (II) and then with ethyl bromoacetate (IV) to give ethyl 1-ethoxycarbonyl-4-piperidone-3-acetate (VI) which is cyclized with hydrazine to (VII). Bromination, reaction with phosphorous oxychloride, and then with benzoylchloride (XI) leads to (XII) which affords the title compound with hydrazine.

参考文献No.950019
标题:Endralazine
作者:Unterhalt, B.
来源:Drugs Fut 1978,3(5),375
合成路线图解说明:

1-Ethoxycarbonyl-4-piperidone (I) is treated with pyrrolidine (II) and then with ethyl bromoacetate (IV) to give ethyl 1-ethoxycarbonyl-4-piperidone-3-acetate (VI) which is cyclized with hydrazine to (VII). Bromination, reaction with phosphorous oxychloride, and then with benzoylchloride (XI) leads to (XII) which affords the title compound with hydrazine.

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