Flordipine, RHC-2906-药物合成数据库

【药物名称】Flordipine, RHC-2906

化学结构式(Chemical Structure):

参考文献No.	804004
标题:	Flordipine
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Thorpe, P.J.
来源:	Drugs Fut 1983,8(9),770

合成路线图解说明: By cyclization of ethyl acetoacetate (I) with 2-trifluoromethylbenzaldehyde (II) and N-(2-aminoethyl)morpholine (III) in refluxing ethanol

合成路线图解说明: By condensation of diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (IV) with N-(2-chloroethyl)morpholine (V) by means of NaH in hot DMF - toluene

参考文献No.	900233
标题:
作者:	Loev, B.; Shroff, J.R. (USV Pharmaceutical Corp.)
来源:	BE 888327; DE 3109794; FR 2480284; GB 2073739; JP 81158762; US 4258042

合成路线图解说明: By cyclization of ethyl acetoacetate (I) with 2-trifluoromethylbenzaldehyde (II) and N-(2-aminoethyl)morpholine (III) in refluxing ethanol

合成路线图解说明: By condensation of diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (IV) with N-(2-chloroethyl)morpholine (V) by means of NaH in hot DMF - toluene