【药物名称】Fluocortin butyl, SH-K-203
化学结构式(Chemical Structure):
参考文献No.900288
标题:
作者:Laurent, H.; et al.
来源:DE 2204361; GB 1387911
合成路线图解说明:

The reaction of 6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (I) with cupric acetate and n-butanol (II) gives compound (III), which is the oxidized with MnO2 in refluxing methylene chloride.

参考文献No.900289
标题:
作者:Laurent, H.; et al.
来源:DE 2150268; FR 2156518; ZA 7201202
合成路线图解说明:

The reaction of 6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (I) with cupric acetate and n-butanol (II) gives compound (III), which is the oxidized with MnO2 in refluxing methylene chloride.

参考文献No.900290
标题:
作者:Laurent, H.; Wiechert, R.
来源:DE 2260303; FR 2209754; NL 7316695
合成路线图解说明:

The reaction of 6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (I) with cupric acetate and n-butanol (II) gives compound (III), which is the oxidized with MnO2 in refluxing methylene chloride.

参考文献No.950031
标题:Fluocortin Butyl
作者:Casta馿r, J.; Hillier, K.
来源:Drugs Fut 1977,2(10),669
合成路线图解说明:

The reaction of 6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (I) with cupric acetate and n-butanol (II) gives compound (III), which is the oxidized with MnO2 in refluxing methylene chloride.

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