Cefazedone-药物合成数据库

【药物名称】Cefazedone

化学结构式(Chemical Structure):

参考文献No.	900291
标题:
作者:	Gericke, R.; et al.
来源:	DE 2345402

合成路线图解说明: The reaction of 7-aminocephalosporanic acid tert-butyl ester (I) with 3,5-dichloro-4-pyridone-1-acetic acid (II) by means of dicyclohexylcarbodiimide in CH2Cl2 gives 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid tert-butyl ester (III), which is hydrolyzed with trifluoroacetic acid yielding the corresponding free acid (IV). Finally this acid is condensed with 5-methyl-1,3,4-thiadiazol-2-thiol (V) by means of NaHCO3 in a hot mixture of water and acetone.

参考文献No.	950032
标题:	Cefazedone
作者:	Casta馿r, J.; Prous, J.R.; Blancafort, P.
来源:	Drugs Fut 1977,2(11),717

合成路线图解说明: The reaction of 7-aminocephalosporanic acid tert-butyl ester (I) with 3,5-dichloro-4-pyridone-1-acetic acid (II) by means of dicyclohexylcarbodiimide in CH2Cl2 gives 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid tert-butyl ester (III), which is hydrolyzed with trifluoroacetic acid yielding the corresponding free acid (IV). Finally this acid is condensed with 5-methyl-1,3,4-thiadiazol-2-thiol (V) by means of NaHCO3 in a hot mixture of water and acetone.