The condensation of 2-chloro-5-trifluoromethylbenzonitrile (I) with 3-fluorothiophenol (II) by means of sodium ethoxide in refluxing ethanol gives 2-(3-fluorophenylthio)-5-trifluoromethylbenzoic acid (III), which is cyclized by means of H2SO4 at 65 C yielding 6-fluoro-2-trifluoromethylthioxanthone (IV). The Grignard reaction of (IV) with 3-dimethylaminopropylmagnesium chloride (V) in refluxing THF affords 6-fluoro-2-trifluoromethyl-9-(3-dimethylaminopropyl)thioxanthene (VII). The condensation of (VII) with N-(2-hydroxyethyl)piperazine (VIII) in isopropanol at 140 C yields 6-fluoro-2-trifluoro-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thioxanthene (IX), which is finally reduced with aqueous HI and red P in refluxing acetic acid.

The condensation of 2-chloro-5-trifluoromethylbenzonitrile (I) with 3-fluorothiophenol (II) by means of sodium ethoxide in refluxing ethanol gives 2-(3-fluorophenylthio)-5-trifluoromethylbenzoic acid (III), which is cyclized by means of H2SO4 at 65 C yielding 6-fluoro-2-trifluoromethylthioxanthone (IV). The Grignard reaction of (IV) with 3-dimethylaminopropylmagnesium chloride (V) in refluxing THF affords 6-fluoro-2-trifluoromethyl-9-(3-dimethylaminopropyl)thioxanthene (VII). The condensation of (VII) with N-(2-hydroxyethyl)piperazine (VIII) in isopropanol at 140 C yields 6-fluoro-2-trifluoro-9-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propylidene]thioxanthene (IX), which is finally reduced with aqueous HI and red P in refluxing acetic acid.