Perafensine hydrochloride, HR-459-药物合成数据库

【药物名称】Perafensine hydrochloride, HR-459

化学结构式(Chemical Structure):

参考文献No.	900303
标题:
作者:	Bartmann, W.; Konz, E.; Geyer, H.M.
来源:	DE 2818403; EP 5232; JP 79148792; US 4282222; ZA 7902018

合成路线图解说明: The oxidation of 3-chloro-1-phenylisoquinoline-4-carbaldehyde (I) with KMnO4 in acetone - aqueous phosphate buffer gives 3-chloro-1-phenylisoquinoline-4-carboxylic acid (II), which is then condensed with piperazine (III) by heating at 150 C to yield the free base (IV). The HCl salt is formed with ethanolic HCl.

参考文献No.	950050
标题:	Perafensine Hydrochloride
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1982,7(8),580

合成路线图解说明: The oxidation of 3-chloro-1-phenylisoquinoline-4-carbaldehyde (I) with KMnO4 in acetone - aqueous phosphate buffer gives 3-chloro-1-phenylisoquinoline-4-carboxylic acid (II), which is then condensed with piperazine (III) by heating at 150 C to yield the free base (IV). The HCl salt is formed with ethanolic HCl.