Amipizone, LU-23051-药物合成数据库

【药物名称】Amipizone, LU-23051

化学结构式(Chemical Structure):

参考文献No.	900307
标题:
作者:	Lebkuecher, R.; Thyes, M.; Koening, H.; Lehmann, H.D.; Gries, J.; Lenke, D.; Kunze, J.
来源:	CA 1108614; DE 2727481; EP 113; JP 7909289

合成路线图解说明: This compound can be obtained by two different ways: 1) The acylation of 2-(4-aminobenzoyl)propionic acid (I) with 2-chloropropionyl chloride (II) in hot toluene gives 2-[4-[(2-chloropropionyl)amino]benzoyl]propionic acid (III), which is then cyclized with hydrazine in refluxing ethanol. 2) By acylation of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (IV) with 2-chloropropionyl chloride (II) in refluxing benzene.

参考文献No.	950053
标题:	Amipizone
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1982,7(10),714

合成路线图解说明: This compound can be obtained by two different ways: 1) The acylation of 2-(4-aminobenzoyl)propionic acid (I) with 2-chloropropionyl chloride (II) in hot toluene gives 2-[4-[(2-chloropropionyl)amino]benzoyl]propionic acid (III), which is then cyclized with hydrazine in refluxing ethanol. 2) By acylation of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (IV) with 2-chloropropionyl chloride (II) in refluxing benzene.