Teoprolol, D-13312(hydrochloride)-药物合成数据库

【药物名称】Teoprolol, D-13312(hydrochloride)

化学结构式(Chemical Structure):

参考文献No.	900310
标题:
作者:	Offermans, H.; Klingler, K.H.; Thiemer, K.; Stroman, F.
来源:	DE 2716210; GB 1527543; US 4144340

合成路线图解说明: Teoprolol has been synthesized as follows: 2-methyl-4-hydroxyindole (I) reacts with epichlorohydrin (II) to the epoxide (III). The alkylation of theophylline alkylamine (IV) with (III) yields teoprolol.

参考文献No.	950055
标题:	Teoprodol
作者:	Klinger, K.H.; Stroman, F.; Thiemer, K.; Engel, J.
来源:	Drugs Fut 1982,7(11),825

合成路线图解说明: Teoprolol has been synthesized as follows: 2-methyl-4-hydroxyindole (I) reacts with epichlorohydrin (II) to the epoxide (III). The alkylation of theophylline alkylamine (IV) with (III) yields teoprolol.