Disobutamide, SC-31828-药物合成数据库

【药物名称】Disobutamide, SC-31828

化学结构式(Chemical Structure):

参考文献No.	900317
标题:
作者:	Renbarger, J.J.; Yonan, P.K.
来源:	BE 864822; DE 2810143; FR 2383163; JP 78121737; US 4107205; US 4153797; ZA 7801429

合成路线图解说明: The reaction of 2-chlorophenylacetonitrile (I) with 2-chloroethyldiisopropylamine (II) by means of NaNH2 in hot toluene gives alpha-[2-(diisopropylamino)ethyl]-2-chloroethyl-2-chlorophenylacetonitrile (III), which is condensed again with 1-(2-chloroethyl)piperidine (IV) by means of NaNH2 in the same way to afford alpha-[2-(1-piperidino)ethyl]-alpha-[2-(diisopropylamino)ethyl]-2-chlorophenylacetonitrile (V). Finally this compound is hydrolyzed partially by means of H2SO4 at 0 C.

参考文献No.	950062
标题:	Disobutamide
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Leeson, P.A.; Mealey, N.E.
来源:	Drugs Fut 1981,6(2),78

合成路线图解说明: The reaction of 2-chlorophenylacetonitrile (I) with 2-chloroethyldiisopropylamine (II) by means of NaNH2 in hot toluene gives alpha-[2-(diisopropylamino)ethyl]-2-chloroethyl-2-chlorophenylacetonitrile (III), which is condensed again with 1-(2-chloroethyl)piperidine (IV) by means of NaNH2 in the same way to afford alpha-[2-(1-piperidino)ethyl]-alpha-[2-(diisopropylamino)ethyl]-2-chlorophenylacetonitrile (V). Finally this compound is hydrolyzed partially by means of H2SO4 at 0 C.