【药物名称】Cipropride
化学结构式(Chemical Structure):
参考文献No.804008
标题:Cipropride
作者:Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Hillier, K.
来源:Drugs Fut 1981,6(4),220
合成路线图解说明:

The esterification of proline (I) with SOCl2 and ethanol gives ethyl prolinate (II), which by treatment with NH3 in methanol is converted into prolinamide (III). The acylation of (III) with cyclopropylcarbonyl chloride (IV) by means of K2CO3 in acetone yields 1-cyclopropylcarbonyl-2-carbamoylpyrrolidine (V), which is reduced with LiAlH4 in ether to afford 1-cyclopropylmethyl-2-aminomethylpyrrolidine (VI) (1,2). Finally this compound is condensed with ethyl 5-sulfamoyl-2-methoxybenzoate (VII) by heating at 120 C

参考文献No.900236
标题:
作者:Kaplan, J.P.; et al. (Synthelabo, S.A.)
来源:BE 857544; DE 2735036; FR 2360572; FR 2372157; FR 2395261; GB 1555890; JP 7825563; NL 7708571; ZA 7704743
合成路线图解说明:

The esterification of proline (I) with SOCl2 and ethanol gives ethyl prolinate (II), which by treatment with NH3 in methanol is converted into prolinamide (III). The acylation of (III) with cyclopropylcarbonyl chloride (IV) by means of K2CO3 in acetone yields 1-cyclopropylcarbonyl-2-carbamoylpyrrolidine (V), which is reduced with LiAlH4 in ether to afford 1-cyclopropylmethyl-2-aminomethylpyrrolidine (VI) (1,2). Finally this compound is condensed with ethyl 5-sulfamoyl-2-methoxybenzoate (VII) by heating at 120 C

参考文献No.900237
标题:
作者:(Synthelabo, S.A.)
来源:BE 861866; FR 2394529; GB 1560019; JP 7905969; NL 7713631; ZA 7706950
合成路线图解说明:

The esterification of proline (I) with SOCl2 and ethanol gives ethyl prolinate (II), which by treatment with NH3 in methanol is converted into prolinamide (III). The acylation of (III) with cyclopropylcarbonyl chloride (IV) by means of K2CO3 in acetone yields 1-cyclopropylcarbonyl-2-carbamoylpyrrolidine (V), which is reduced with LiAlH4 in ether to afford 1-cyclopropylmethyl-2-aminomethylpyrrolidine (VI) (1,2). Finally this compound is condensed with ethyl 5-sulfamoyl-2-methoxybenzoate (VII) by heating at 120 C

参考文献No.900238
标题:
作者:Obitz, D.C.L. (Synthelabo, S.A.)
来源:FR 2393794
合成路线图解说明:

The esterification of proline (I) with SOCl2 and ethanol gives ethyl prolinate (II), which by treatment with NH3 in methanol is converted into prolinamide (III). The acylation of (III) with cyclopropylcarbonyl chloride (IV) by means of K2CO3 in acetone yields 1-cyclopropylcarbonyl-2-carbamoylpyrrolidine (V), which is reduced with LiAlH4 in ether to afford 1-cyclopropylmethyl-2-aminomethylpyrrolidine (VI) (1,2). Finally this compound is condensed with ethyl 5-sulfamoyl-2-methoxybenzoate (VII) by heating at 120 C

参考文献No.900239
标题:
作者:Kaplan, J.P.; et al. (Synthelabo, S.A.)
来源:BE 836752; CA 1039731; CH 612668; DE 2556457; FR 2294698; FR 2327771; FR 2331345; GB 1508880; JP 7748661; NL 7514620; US 4021567; US 4156060; US 4172143; US 4189495; ZA 7507828
合成路线图解说明:

The esterification of proline (I) with SOCl2 and ethanol gives ethyl prolinate (II), which by treatment with NH3 in methanol is converted into prolinamide (III). The acylation of (III) with cyclopropylcarbonyl chloride (IV) by means of K2CO3 in acetone yields 1-cyclopropylcarbonyl-2-carbamoylpyrrolidine (V), which is reduced with LiAlH4 in ether to afford 1-cyclopropylmethyl-2-aminomethylpyrrolidine (VI) (1,2). Finally this compound is condensed with ethyl 5-sulfamoyl-2-methoxybenzoate (VII) by heating at 120 C

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