Moxipraquine, 349-C-59-药物合成数据库

【药物名称】Moxipraquine, 349-C-59

化学结构式(Chemical Structure):

参考文献No.	803995
标题:	Moxipraquine
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Hillier, K.
来源:	Drugs Fut 1981,6(6),356

合成路线图解说明: The reaction of 8-(6-bromocaproamido)-6-methoxyquinoline (I) with N-(3-hydroxy-n-butyl)piperazine (II) by means of triethylamine in refluxing benzene gives 8-[6-[4-(3-hydroxy-n-butyl)piperazin-1-yl]-1-oxohexylamino]-6-methoxyquinoline (III), which is reduced with LiAlH4 in refluxing THF

参考文献No.	900224
标题:
作者:	Wall, L.P. (Wellcome Foundation, Ltd.)
来源:	GB 1153471

合成路线图解说明: The reaction of 8-(6-bromocaproamido)-6-methoxyquinoline (I) with N-(3-hydroxy-n-butyl)piperazine (II) by means of triethylamine in refluxing benzene gives 8-[6-[4-(3-hydroxy-n-butyl)piperazin-1-yl]-1-oxohexylamino]-6-methoxyquinoline (III), which is reduced with LiAlH4 in refluxing THF