Dazolicine, UCB-B-192-药物合成数据库

【药物名称】Dazolicine, UCB-B-192

化学结构式(Chemical Structure):

参考文献No.	803990
标题:	Dazolicine
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Koch, H.
来源:	Drugs Fut 1981,6(9),540

合成路线图解说明: The reaction of 8-chloro-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (I) with chloroacetonitrile (II) by means of Na2CO3 at 90 C gives 8-chloro-6-cyanomethyl-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (III), which is cyclized with N-isopropylethylenediamine (IV) by heating at 110 C with some CS2

参考文献No.	900220
标题:
作者:	Zivkovic, D. (UCB (Union Chimique-Chemisque Bedrijven) S.A.)
来源:	BE 727977; CA 897161; DE 1905525; GB 1191963; JP 7213912; NL 6901745; US 366927

合成路线图解说明: The reaction of 8-chloro-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (I) with chloroacetonitrile (II) by means of Na2CO3 at 90 C gives 8-chloro-6-cyanomethyl-3,4,5,6-tetrahydro-2H-1,6-benzothiazocine (III), which is cyclized with N-isopropylethylenediamine (IV) by heating at 110 C with some CS2