Cianergoline, 355/1057-药物合成数据库

【药物名称】Cianergoline, 355/1057

化学结构式(Chemical Structure):

参考文献No.	950040
标题:	Antihypertensive ergolinepropionamides
作者:	Bernardi, L.; Bosisio, G.; Mantegani, S.; Sapini, O.; Temperelli, A.; Salvati, P.; Di Salle, E.; Arcari, G.; Bianchi, G.
来源:	Arzneim-Forsch 1983,331094

合成路线图解说明: By reaction of 6-methylergoline-8beta-methanol p-toluenesulfonate (I) with ethyl cyanoacetate (II), potassium tert-butylate and potassium iodide to give ethyl alpha-cyano-6-methylergoline-8beta-propionate (III) which is treated with ammonia. A slightly modified synthesis has also been described.

参考文献No.	950041
标题:	Cianergoline
作者:	Riva, F.; Sardi, A.
来源:	Drugs Fut 1984,9(1),13

合成路线图解说明: By reaction of 6-methylergoline-8beta-methanol p-toluenesulfonate (I) with ethyl cyanoacetate (II), potassium tert-butylate and potassium iodide to give ethyl alpha-cyano-6-methylergoline-8beta-propionate (III) which is treated with ammonia. A slightly modified synthesis has also been described.