CVT-2759-药物合成数据库

【药物名称】CVT-2759

化学结构式(Chemical Structure):

参考文献No.	49594
标题:	N6 Heterocylic 5' modified adenosine derivs.
作者:	Belardinelli, L.; Zablocki, J.A.; Palle, V.P.; Ibrahim, P.N.; Varkhedkar, V. (CV Therapeutics, Inc.)
来源:	US 6258793; WO 0140244; WO 0140245

合成路线图解说明: The reaction of the chloropurine (I) with tetrahydrofuran-2(R)-amine (II) gives N6-(furan-2(R)-yl)adenosine (III), which is treated with 2,2-dimethoxypropane and Ts-OH in hot DMF to yield N6-(furan-2-(R)-yl)-2'O,3'O-isopropylideneadenosine (IV). The reaction of (IV) with CDI and methylamine in THF affords N6-(furan-2-(R)-yl)-2'O,3'O-isopropylidene-5'O-(N-methylcarbamoyl)adenosine (V), which is finally deprotected with HOAc in hot water to provide the target adenosine derivative.

参考文献No.	661995
标题:	A1 adenosine receptor agonist- SAR of 5'-carbamates and 5'-thionocarbamates of N6-substituted adenosine derivatives
作者:	Palle, V.P.; et al.
来源:	223rd ACS Natl Meet (April 7 2002, Orlando) 2002,Abst MEDI 23

合成路线图解说明: The reaction of the chloropurine (I) with tetrahydrofuran-2(R)-amine (II) gives N6-(furan-2(R)-yl)adenosine (III), which is treated with 2,2-dimethoxypropane and Ts-OH in hot DMF to yield N6-(furan-2-(R)-yl)-2'O,3'O-isopropylideneadenosine (IV). The reaction of (IV) with CDI and methylamine in THF affords N6-(furan-2-(R)-yl)-2'O,3'O-isopropylidene-5'O-(N-methylcarbamoyl)adenosine (V), which is finally deprotected with HOAc in hot water to provide the target adenosine derivative.