ORG-25969-药物合成数据库

【药物名称】ORG-25969

化学结构式(Chemical Structure):

参考文献No.	49625
标题:	6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block
作者:	Bennet, D.J.; Palin, R.; Zhang, M. (Akzo Nobel N.V.)
来源:	WO 0140316

合成路线图解说明: Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound

参考文献No.	664983
标题:	Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships
作者:	Adam, J.M.; Bennet, D.J.; Bom, A.; Clark, J.K.; Feilden, H.; Hutchinson, E.J.; Palin, R.; Prosser, A.; Rees, D.C.; Rosair, G.M.; Stevenson, D.; Tarver, G.J.; Zhang, M.Q.
来源:	J Med Chem 2002,45(9),1806

合成路线图解说明: Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound