【药物名称】
化学结构式(Chemical Structure):
参考文献No.630505
标题:An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-on, a novel antitumor agent
作者:Tomoda, A.; Arai, S.; Ishida, R.; Shimamoto, T.; Ohnyashiki, K.
来源:Bioorg Med Chem Lett 2001,11(8),1057
合成路线图解说明:

The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2, through the intermediate quinonimine (II). The reaction was performed with bovine hemolysates and also with purified human hemoglobin.

参考文献No.631489
标题:Phenoxazinone synthesis by human hemoglobin
作者:Tomoda, A.; Hamashima, H.; Arisawa, M.; Kikuchi, T.; Tezuka, Y.; Koshimura, S.
来源:Biochim Biophys Acta 1992,117(3),306
合成路线图解说明:

The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2, through the intermediate quinonimine (II). The reaction was performed with bovine hemolysates and also with purified human hemoglobin.

参考文献No.631490
标题:Antitumor activity of 2-amino-4,4 alpha-dihydro-4 alpha, 7-dimethyl-3H-phenoxazine-3-one, a novel phenoxazine derivative produced by the reaction of 2-amino-5-methylphenol with bovine hemolysate
作者:Ishida, R.; Yamanaka, S.; Kawai, H.; Ito, H.; Iwai, M.; Nishizawa, M.; Hamatake, M.; Tomoda, A.
来源:Anti-Cancer Drugs 1996,7(5),591
合成路线图解说明:

The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2, through the intermediate quinonimine (II). The reaction was performed with bovine hemolysates and also with purified human hemoglobin.

参考文献No.698132
标题:Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo
作者:Shimamoto, T.; Tomoda, A.; Ishida, R.; Ohyashiki, K.
来源:Clin Cancer Res 2001,7(3),704
合成路线图解说明:

The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2, through the intermediate quinonimine (II). The reaction was performed with bovine hemolysates and also with purified human hemoglobin.

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