2,7-Dibromocryptolepine-药物合成数据库

【药物名称】2,7-Dibromocryptolepine

化学结构式(Chemical Structure):

参考文献No.	631347
标题:	Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents
作者:	Wright, C.W.; Addae-Kyereme, J.; Breen, A.G.; Brown, J.E.; Cox, M.F.; Croft, S.L.; Gokcek, Y.; Kendrick, H.; Phillips, R.M.; Pollet, P.L.
来源:	J Med Chem 2001,44(19),3187

合成路线图解说明: The condensation between 5-bromoisatin (I) and 3-acetoxy-1-acetyl-5-bromoindole (II) under basic conditions in an oxygen-free atmosphere produced the quindoline-11-carboxylic acid (III). This was decarboxylated to the dibromoquindoline (IV) upon heating in diphenyl ether. Finally, methylation of (IV) using iodomethane in tetramethylenesulfone furnished the title dibromocryptolepine.