Lotifazole, F-1686-药物合成数据库

【药物名称】Lotifazole, F-1686

化学结构式(Chemical Structure):

参考文献No.	900322
标题:
作者:
来源:	EP 1727; FR 2406634; JP 7961172

合成路线图解说明: The cyclization of acetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-phenyl-2-aminothiazole (III), which is then condensed with 2,2,2-trichloroethyl chloroformate (IV) by means of NaHCO3 in acetone.

参考文献No.	950068
标题:	Lotifazole
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1981,6(10),624

合成路线图解说明: The cyclization of acetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-phenyl-2-aminothiazole (III), which is then condensed with 2,2,2-trichloroethyl chloroformate (IV) by means of NaHCO3 in acetone.