Eniclobrate, Sgd-33374(hydrochloride)-药物合成数据库

【药物名称】Eniclobrate, Sgd-33374(hydrochloride)

化学结构式(Chemical Structure):

参考文献No.	900339
标题:
作者:	Thiele, K.; et al.
来源:	BE 823904; CH 601169; CH 605557; CH 605642; DE 2461069; FR 2255891; GB 1497266; JP 75105621; NL 7416412; US 4115393; US 4153803

合成路线图解说明: The condensation of 4-chloro-4?hydroxydiphenylmethane (I) with ethyl 2-bromo-2-methylbutyrate (II) by means of K2CO3 in refluxing xylene gives ethyl 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyrate (III), which by hydrolysis with KOH in refluxing ethanol is converted into the corresponding free acid (IV). The reaction of (IV) with refluxing SOCl2 affords 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyryl chloride (V), which is finally esterified with 3-hydroxymethylpyridine (VI) by means of pyridine in refluxing benzene.

参考文献No.	950086
标题:	Eniclobrate
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Hillier, K.
来源:	Drugs Fut 1980,5(5),237

合成路线图解说明: The condensation of 4-chloro-4?hydroxydiphenylmethane (I) with ethyl 2-bromo-2-methylbutyrate (II) by means of K2CO3 in refluxing xylene gives ethyl 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyrate (III), which by hydrolysis with KOH in refluxing ethanol is converted into the corresponding free acid (IV). The reaction of (IV) with refluxing SOCl2 affords 2-[4-(4-chlorobenzyl)phenoxy]-2-methylbutyryl chloride (V), which is finally esterified with 3-hydroxymethylpyridine (VI) by means of pyridine in refluxing benzene.