Fuprazole-药物合成数据库

【药物名称】Fuprazole

化学结构式(Chemical Structure):

参考文献No.	900354
标题:
作者:	Fauran, C.; et al.
来源:	BE 835132; CA 1002042; CH 578561; DE 2552151; FR 2291755; GB 1487143; JP 7675081; JP 7941596; NL 7513599; US 4029879; ZA 7506925

合成路线图解说明: The reaction of 1-[2-(alpha-furoyl)ethyl]piperazine (I) with 2-hydroxymethylbenzimidazol (II) in refluxing ethanol - water gives 1-[2-(alpha-furoyl)ethyl]-2-hydroxymethylbenzimidazol (III), which by reaction with SOCl2 in chloroform is converted to 1-[2-(alpha-furoyl)ethyl]-1-chloromethylbenzimidazol (IV). Finally this compound is condensed with 1-cinnamylpiperazine (V) by means of Na2CO3 in refluxing ethyl acetate.

参考文献No.	950103
标题:	Fuprazole
作者:	Blancafort, P.; Serradell, M.N.; Casta馿r, J.; Thorpe, J.F.
来源:	Drugs Fut 1980,5(12),608

合成路线图解说明: The reaction of 1-[2-(alpha-furoyl)ethyl]piperazine (I) with 2-hydroxymethylbenzimidazol (II) in refluxing ethanol - water gives 1-[2-(alpha-furoyl)ethyl]-2-hydroxymethylbenzimidazol (III), which by reaction with SOCl2 in chloroform is converted to 1-[2-(alpha-furoyl)ethyl]-1-chloromethylbenzimidazol (IV). Finally this compound is condensed with 1-cinnamylpiperazine (V) by means of Na2CO3 in refluxing ethyl acetate.