Plafibride, ITA-104-药物合成数据库

【药物名称】Plafibride, ITA-104

化学结构式(Chemical Structure):

参考文献No.	900356
标题:
作者:	Iniesta, J.
来源:	DE 2716374; ES 447114

合成路线图解说明: The reaction of 2-(p-chlorophenoxy)isobutyric acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with urea (III) in refluxing benzene yielding 2-(p-chlorophenoxy)isobutyrylurea (IV). The aminomethylation of (IV) with formaldehyde and morpholine (V) affords N-2-(p-chlorophenoxy)isobutyryl-N'-morpholinomethylurea which can be further purified through hydrochloride salt.

参考文献No.	950105
标题:	Plafibride
作者:	Ribalta, M.; Bruseghini, L.
来源:	Drugs Fut 1979,4(1),42

合成路线图解说明: The reaction of 2-(p-chlorophenoxy)isobutyric acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with urea (III) in refluxing benzene yielding 2-(p-chlorophenoxy)isobutyrylurea (IV). The aminomethylation of (IV) with formaldehyde and morpholine (V) affords N-2-(p-chlorophenoxy)isobutyryl-N'-morpholinomethylurea which can be further purified through hydrochloride salt.