The Grignard reaction of 2-hydroxymethylcyclohexanone (I) with phenyl magnesium bromide (II) in ether gives 2-hydroxymethyl-1-phenylcyclohexanol (III), which by oxidation with KMnO4 in water containing Na2CO3 is converted into 2-phenyl-2-hydroxycyclohexanecarboxylic acid (IV). The reduction of (IV) with H2 over PtO2 in acetic acid at 80 C and 22 Kg/cm2 affords 2-cyclohexyl-2-hydroxycyclohexanecarboxylic acid (V) (1,2), which is esterified with 1-bromo-2-propanol (VI) by means of 85% H2SO4 yielding 1-bromoisopropyl-2-cyclohexyl-2-hydroxycyclohexanecarboxylate (VII). Finally this compound is treated with diethylamine (VIII) and triethylamine at 120 C (2).

The Grignard reaction of 2-hydroxymethylcyclohexanone (I) with phenyl magnesium bromide (II) in ether gives 2-hydroxymethyl-1-phenylcyclohexanol (III), which by oxidation with KMnO4 in water containing Na2CO3 is converted into 2-phenyl-2-hydroxycyclohexanecarboxylic acid (IV). The reduction of (IV) with H2 over PtO2 in acetic acid at 80 C and 22 Kg/cm2 affords 2-cyclohexyl-2-hydroxycyclohexanecarboxylic acid (V) (1,2), which is esterified with 1-bromo-2-propanol (VI) by means of 85% H2SO4 yielding 1-bromoisopropyl-2-cyclohexyl-2-hydroxycyclohexanecarboxylate (VII). Finally this compound is treated with diethylamine (VIII) and triethylamine at 120 C (2).

The Grignard reaction of 2-hydroxymethylcyclohexanone (I) with phenyl magnesium bromide (II) in ether gives 2-hydroxymethyl-1-phenylcyclohexanol (III), which by oxidation with KMnO4 in water containing Na2CO3 is converted into 2-phenyl-2-hydroxycyclohexanecarboxylic acid (IV). The reduction of (IV) with H2 over PtO2 in acetic acid at 80 C and 22 Kg/cm2 affords 2-cyclohexyl-2-hydroxycyclohexanecarboxylic acid (V) (1,2), which is esterified with 1-bromo-2-propanol (VI) by means of 85% H2SO4 yielding 1-bromoisopropyl-2-cyclohexyl-2-hydroxycyclohexanecarboxylate (VII). Finally this compound is treated with diethylamine (VIII) and triethylamine at 120 C (2).