【药物名称】Nibroxane, Compound 85287
化学结构式(Chemical Structure):
参考文献No.900362
标题:
作者:Lappas, L.C.; Hirsch, C.A.
来源:US 4025533
合成路线图解说明:

The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III), which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1). Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).

参考文献No.900363
标题:
作者:Lappas, L.C.; Hirsch,C.A.
来源:DE 2407289; FR 2218096; JP 74110674; NL 7402164; ZA 7400493
合成路线图解说明:

The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III), which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1). Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).

参考文献No.950114
标题:Substituted 5-nitro-1,3-dioxanes: correlation of chemical structure and antimicrobial activity
作者:Lappas, L.C.; et al.
来源:J Pharm Sci 1979,65(9),1301-1305
合成路线图解说明:

The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III), which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1). Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).

参考文献No.950115
标题:Nibroxane
作者:Hillier, K.
来源:Drugs Fut 1979,4(5),348
合成路线图解说明:

The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III), which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1). Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).

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