Piflutixol-药物合成数据库

【药物名称】Piflutixol

化学结构式(Chemical Structure):

参考文献No.	900414
标题:
作者:	Buus, J.M.L.; et al.
来源:	DE 2631389

合成路线图解说明: The Grignard reaction of 2-trifluoromethyl-6-fluorothioxanthone (I) with allylmagnesium bromide (II) in ether gives 2-trifluoromethyl-6-fluoro-9-(2-propenylidene)thioxanthene (III), which is then condensed with 4-(2-hydroxyethyl)piperidine (IV) at 90 C.

参考文献No.	950172
标题:	Piflutixol
作者:	Casta馿r, J.; Owen, R.T.
来源:	Drugs Fut 1978,3(9),670

合成路线图解说明: The Grignard reaction of 2-trifluoromethyl-6-fluorothioxanthone (I) with allylmagnesium bromide (II) in ether gives 2-trifluoromethyl-6-fluoro-9-(2-propenylidene)thioxanthene (III), which is then condensed with 4-(2-hydroxyethyl)piperidine (IV) at 90 C.