【药物名称】Tolmesoxide, RX-71107
化学结构式(Chemical Structure):
参考文献No.900415
标题:
作者:Bentley, K.W.; Rushworth,W.I.
来源:GB 1337576
合成路线图解说明:

The methylation of 4,5-dimethoxy-2-methylthiophenol (I) with dimethyl sulfate by means of sodium ethoxide in refluxing ethanol gives 4,5-dimethoxy-2-methylphenyl methyl sulfide (II), which is then oxidized with H2O2 in glacial acetic acid.

参考文献No.900416
标题:
作者:Bentley, J.M.; Rushworth, W.I.
来源:CA 960697; DE 2160148; FR 2116579; GB 1337575; US 3804904; US 3886285; ZA 7107860
合成路线图解说明:

The methylation of 4,5-dimethoxy-2-methylthiophenol (I) with dimethyl sulfate by means of sodium ethoxide in refluxing ethanol gives 4,5-dimethoxy-2-methylphenyl methyl sulfide (II), which is then oxidized with H2O2 in glacial acetic acid.

参考文献No.950173
标题:Tolmesoxide
作者:Casta馿r, J.; Hillier, K.
来源:Drugs Fut 1978,3(9),691
合成路线图解说明:

The methylation of 4,5-dimethoxy-2-methylthiophenol (I) with dimethyl sulfate by means of sodium ethoxide in refluxing ethanol gives 4,5-dimethoxy-2-methylphenyl methyl sulfide (II), which is then oxidized with H2O2 in glacial acetic acid.

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