Meseclazone, W-2395-药物合成数据库

【药物名称】Meseclazone, W-2395

化学结构式(Chemical Structure):

参考文献No.	803969
标题:	Meseclazone
作者:	Casta馿r, J.; Arrigoni, Martelli, E.
来源:	Drugs Fut 1977,2(6),380

合成路线图解说明: By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III), which is finally cyclized again with aqueous NaOH, or sodium methoxide in methanol

参考文献No.	900204
标题:
作者:	Reisner, D.B.; et al. (Carter-Wallace, Inc.)
来源:	DE 2010418; US 3598814

合成路线图解说明: By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III), which is finally cyclized again with aqueous NaOH, or sodium methoxide in methanol