【药物名称】KPN-2001
化学结构式(Chemical Structure):
参考文献No.633012
标题:Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis
作者:Miyamoto, T.; et al.
来源:Tetrahedron Lett 2001,42(36),6349
合成路线图解说明:

Ozonolysis of cholesterol (I) in Et2O at -78 C, followed by reductive treatment of the intermediate ozonide with dimethyl sulfide, produced the keto aldehyde cleaved compound (II). Intramolecular aldol condensation of (II) in the presence of LDA in cold THF furnished the title sterol.

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